The Best Vitamin B12 Supplements


The Best Vitamin B12 Supplement of 2020

The most thorough comparison of over 100 B12 Supplements ever done!

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Vitamin B12 And Stroke Risk - UPDATE BY Dr. Michael Gregor

Vitamin B-12 Deficiency is linked to stroke risk.

The leading expert on nutrition, diet and supplements Dr.Michael Gregor from Nutritionfacts.Org discusses why and what you can do about it in his recent video.


All About Vitamin B12

Vitamin B12 is an essential vitamin that your body cannot produce on it’s own and therefore it must be consumed through diet.

About 2.4mcg per day of vitamin B12 is required for many healthy body functions including healthy nerves and blood as well as DNA production.

Studies indicate that up to 15% of the US population may be deficient in vitamin B12 and deficiencies are most common in older adults, vegans, people on Metformin, and people with nutrient absorption issues. (1)

It is important to treat B12 deficiency as soon as possible since it can damage the nervous system or possibly contribute to heart disease or stroke.

B12 deficiency may cause tiredness, weakness, loss of appetite, constipation, balance issues, dementia, depression, confusion, poor memory and anemia.

Proven Benefits Of Vitamin B12

Vitamin B12 for hair skin and nails.

Studies indicate that Vitamin B12 supplements may help prevent the risk of age-related macular degeneration. (2) and well as maintaining healthy hair, skin and nails. (8, 9)

Improve energy with Vitamin B12

Supplementing with vitamin B12 has been shown to improve energy in people with B12 deficiency and prevent tiredness and weakness in healthy individuals(3, 4)

Improve mood with vitamin B12

Studies show improvements in mood and depression symptoms when increasing vitamin B12 (5, 6, 7)

Important facts about

Vitamin B12 supplements you should know

Finding The Best Vitamin B12 Supplement

What You Need To Know

  • Many vitamin B12 supplements we reviewed come in very high doses of 1000mcg up to 5000mcg which may be best for a B12 deficiency and short term treatment only.
  • It was difficult for us to find the best B12 products since many of the top sellers were not cGMP, or were not third party tested leaving us uncertain of their quality.
  • Although B12 is water soluble and there is no safe upper limit, it is recommended by some doctors that B12 supplements used as a daily maintenance dose should be in a smaller safer dose between 50mcg and 500mcg.
  •  Recent studies indicate that high levels of vitamin B12 in the blood have been linked to increase risk of health issues like heart disease, stroke, increase death, autism in newborns and skin issues. ( 10 )

Questions About Vitamin B12

Which form of vitamin B12 is best?

The two primary types of Vitamin B12 used in supplements is Methylcobalamin and Cyanocobalamin. It is said that the more natural form of Methylcobalamin is the most active form of B12 and is retained in the tissues better than the synthetic Cyanocobalamin and is used much more efficiently by the liver, brain and nervous system. This is why we that the best Vitamin B12 supplement is the Methylcobalamin form.

How much B12 should you take a day?

If you are already very depleted in Vitamin B-12 and are already experiencing Vitamin B12 deficiency health issues then the best vitamin B12 supplement for you would be one with higher amounts in the 1000mcg to 5000mcg range. But, for those individuals that just want a daily maintenance dose we recommend 500mg to 1000mcg per day. If you take too much Vitamin B12 the body will only absorb what it needs and the rest will be removed in the urine.

Are B12 supplements effective?

Taking a daily vitamin B12 supplement can be as effective as getting a once a month Vitamin B12 injection and that can prevent vitamin B12 deficiencies.

When is the best time to take Vitamin B12 supplements?

Vitamin B-12 may boost energy so it’s best to take it earlier in the day.

What should I take my Vitamin B12 supplements with?

Vitamin B-12 seams to be better absorbed on an empty stomach so it may be best to take it with a glass of water 30 minutes before a meal. If you have a sensitive stomach taking it with a meal is OK to.

How long does it take for B12 supplements to work?

If you are taking one of the best vitamin B12 supplements available it is said that vitamin B12 levels can be elevated within 24 to 72 hours which is when you may start noticing some changes.

How do I know if I'm getting enough B12?

If you start to feel any of the known symptoms of Vitamin B deficiency such as weakness and fatigue,  pale or jaundice skin, pins and needles feeling, inflamed tongue or mouth Ulcers, changes to mobility, breathlessness or dizziness, blurred vision or eye issues, mood swings, or a higher than normal body temperature it may be wise to the best vitamin B12 supplements below to see if your symptoms subside. You can also check with your doctor and have some blood tests done.

How can I increase my B12 naturally?

B-12 is commonly found in foods such as beef, liver, chicken, dairy and fortified foods such as cereals, however, recent guidelines from the American Cancer Society suggest links to cancer from red and processed meats and other processed foods. Also, research has shown that the consumption of dairy, meat and other animal based foods may be linked to twice the risk of heart disease and stroke.

So if you are looking to improve your overall health, and get enough Vitamin B12 then a vegan Vitamin B12 supplement combined with a healthy plant based diet and increased exercise is highly recommended.

Are there plant sources of Vitamin B12?

Vitamin B12 usually comes from bacteria found in water and can be found on the plants that animals eat and since our water is filtered and the plants we eat are thoroughly washed it’s hard to get Vitamin B from plant sources.

At this time there are no known good sources of plant based vitamin B12.

Are there any side effects of taking B12 supplements?

There are little to no side effects to oral vitamin B12 supplements in suggested amounts and for prolonged use however we do not recommend supplements with doses over 2000mcg because high levels of vitamin B12 in the blood have been linked to increase risk of health issues like heart disease, stroke, increase death, autism in newborns and skin issues. ( 10 )

Are B12 shots better than pills?

B12 injections are a quick and effective way to increase vitamin B12 levels in individuals experiencing health issues from a B12 deficiency, but we believe that getting a smaller more natural dose of Vitamin B12 either daily or weekly may be better for your health especially since high levels of vitamin B12 in the blood have been linked to increase risk of health issues like heart disease, stroke, increase death, autism in newborns and skin issues. ( 10 )

Does B12 help you sleep?

Vitamin B-12 may help regulate the levels of the amino acid Tryptophan which may help improve the body’s natural production of sleep-inducing Melatonin.

Is Vitamin B12 good for hair and skin?

B12 deficiency impacts hair and skin quality. The vitamin is required to produce new hair cells and promote hair growth and Vitamin B12 may help to helping to prevent dark spots and pigmentation issues and may also help in the growth of healthy skin cells.

How much vitamin B12 should a person over 65 take?

A healthy body may only be able to absorb a fraction (about 2%) of the vitamin B12 in supplements, therefore daily doses of a supplement with only 124mcg should be sufficient per day, however if you are older you ability to absorption Vitamin B12 may be even less so the best vitamin B12 supplement for older adults may be closer to 500mcg to 1000mcg especially if you’re not already acquiring sufficient amounts from your daily diet. ( 11 )

Does B12 give you energy?

If you are deficient in B12 you may be experiencing tiredness and taking the best vitamin B12 supplements may cause an increase in energy. If you want to boost energy you should consider CoQ10 or  Ashwagandha supplements. It also makes a lot of sense to eat and healthier diet and many people that switch to a plant based diet notice an improvement in energy within a few weeks.

A raw food sourced vegan Vitamin B12 in 500mcg to 1000mcg per day may be best for daily use.

The Best Vitamin B12 Supplement of 2020

The Best Vitamin B12 Supplement of 2020

We compared over 100 of the most popular Vitamin B12 Supplements to find the best Vitamin B12 Supplement of 2020.


Key Features /Pro’s

  • Each serving provides 500mcg of organic B-12 in the form of methylcobalamin, which is the highly absorbable, active, and natural form of B-12, derived from natural food source of Saccharomyces cerevisiae.
  • In a safer daily dose serving size and not mega-dose serving size like other supplements.
  • Spray form for better absorption.
  • Vegan, Non-GMO and Organic.
  • High quality and made in a cGMP facility.
  • 3rd party tested
  • Only 9 cents* per serving. 
  • Raw ingredients go through quality control process and vigorous testing.  
  • Made in the USA.

The Top 3 Best Vitamin B12 Supplements Of 2020


  • Liquid – 500mcg of organic B-12 in the form of Methylcobalamin
  • .09 cents per serving
  • 140 servings per bottle
  • 3rd-Party Tested
  • USDA Organic Certified
  • certified cGMP
  • 2675 – 4.5 star reviews
  • Amazon’s Choice Product


  • Vegan
  • 1000mcg Methylcobalamin Raw B-12
  • .46 cents per serving
  • 30 Capsules
  • 3rd-Party Tested
  • manufactured in cGMP (current Good Manufacturing Practices) third-party audited facilities


  • .09 cents per serving
  • 1000mcg Methylcobalamin B-12
  • 180 quick dissolve chewable tablets
  • 3rd-Party Tested
  • manufactured in cGMP (current Good Manufacturing Practices) third-party audited facilities


In the know!

The book titled “Could it be B12?” , gets a high 4.12 rating on the website and has aided readers in understanding B12 in more detail and has helped with treating symptoms related to vitamin B12 deficiencies.


Could It Be B12? Pediatric Edition: What Every Parent Needs to Know about Vitamin B12 Deficiency


The Supplement Handbook: A Trusted Expert’s Guide to What Works & What’s Worthless for More Than 100 Conditions


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